已有大量文獻及大學科研指出[1]，來自選定生物治療細菌的微粉化細胞 (MC) 是否能夠有效調節單核細胞/巨噬細胞亞群的極化，從而有利地提供抵禦感染的第一道防線。使用乳雙歧桿菌BS01 菌株中獲得 MC 結果表明，源自生物治療菌株BS01 的MC 代表一種可能療法，旨在有效預防和/或治療病毒、細菌、真菌或原蟲疾病，以及預防和/或治療由外部病原體引發的發炎過程
特定菌株可作用於腸腔環境、腸道黏膜屏障，調節黏膜免疫系統。益生菌可能影響涉及先天性和後天免疫的不同細胞，例如DC、單核細胞、自然殺手(NK)細胞、巨噬細胞、淋巴細胞和上皮細胞。特別是它們可以激活免疫細胞（即集合淋巴結中的M細胞）和非免疫細胞（即腸上皮細胞）上表達的模式識別受體（PRR ）。[2]
Bifidobacterium animalis subsp. lactis BS01、Lactobacillus rhamnosus LR04 和 Lactobacillus plantarum LP02 都是具有顯著免疫力增強作用的益生菌。
以下是針對免疫力的詳細好處：
Bifidobacterium animalis subsp. lactis BS01
* 增強免疫系統功能：刺激免疫系統中的巨噬細胞和自然殺傷細胞（NK細胞）的活性，增強對抗病原體的能力。
增加抗體（如免疫球蛋白A，IgA）的生成，幫助抵抗感染。
* 減少呼吸道感染：研究顯示，補充 BS01 能夠降低上呼吸道感染的發生率，特別是在兒童和老年人群體中。
* 抗炎作用：減少腸道和全身性的炎症反應，有助於緩解慢性炎症相關的健康問題。
Lactobacillus rhamnosus LR04
*調節免疫反應：促進免疫系統中的調節性T細胞（Treg）的生成，幫助維持免疫平衡，減少過敏和自體免疫反應。
*增強腸道免疫屏障：增加腸道內免疫細胞的數量和活性，提高腸道屏障功能，減少腸道感染的風險。
*減少過敏反應：研究表明，LR04 能夠減少過敏性疾病（如濕疹和過敏性鼻炎）的發生率和嚴重程度。
Lactobacillus plantarum LP02
增強全身免疫反應：刺激免疫系統的不同成分，包括巨噬細胞、T細胞和B細胞，增強整體免疫反應。
增加體內抗體的生成，提高對病原體的抵抗力。
抗病毒特性：研究顯示，LP02 能夠增強宿主對病毒感染的抵抗能力，特別是流感病毒和腸病毒。
抗菌作用：具有天然的抗菌特性，能夠抑制有害細菌的生長，如沙門氏菌和大腸桿菌，有助於預防和減少腸道感染。
研究支持
Bifidobacterium animalis subsp. lactis BS01：
臨床研究顯示，BS01 能夠顯著提高免疫細胞的活性，減少呼吸道感染的發生率，並有助於降低炎症標記物的水平。
Lactobacillus rhamnosus LR04：
該益生菌被證實能夠調節免疫系統，減少過敏反應，並在腸道健康和免疫調節方面展示了顯著的效果。
Lactobacillus plantarum LP02：
臨床試驗表明，LP02 能夠增強全身免疫反應，特別是在抗病毒和抗菌方面，並能夠顯著提高抗體水平。
實際應用
口服補充劑：這些益生菌通常以口服補充劑的形式存在，可以通過定期攝取來增強免疫力。
總結來說，Bifidobacterium animalis subsp. lactis BS01、Lactobacillus rhamnosus LR04 和 Lactobacillus plantarum LP02 都在增強免疫力方面展示了顯著的潛力。它們通過多種機制（如增強免疫細胞活性、增加抗體生成、調節免疫反應等）來支持和增強免疫系統的功能，有助於預防和減少感染及過敏反應。建議在使用這些益生菌補充劑之前，諮詢醫療專業人士的建議，特別是如果你有特殊的健康狀況或正在服用其他藥物。
A large amount of literature and university scientific research have pointed out [1] whether micronized cells (MC) from selected biotherapeutic bacteria can effectively regulate the polarization of monocyte/macrophage subpopulations, thereby favorably providing a second line of defense against infection. A line of defense. MC obtained using Bifidobacterium lactis BS01 strain The results indicate that MC derived from the biotherapeutic strain BS01 represents a possible therapy aimed at the effective prevention and/or treatment of viral, bacterial, fungal or protozoal diseases, as well as the prevention and/or treatment of Inflammatory process triggered by external pathogens
Specific strains can act on the intestinal lumen environment and intestinal mucosal barrier to regulate the mucosal immune system. Probiotics may affect different cells involved in innate and acquired immunity, such as DCs, monocytes, natural killer (NK) cells, macrophages, lymphocytes and epithelial cells. In particular, they can activate pattern recognition receptors (PRRs) expressed on immune cells (i.e., M cells in Peyer's patches) and non-immune cells (i.e., intestinal epithelial cells). [2]
Bifidobacterium animalis subsp. lactis BS01, Lactobacillus rhamnosus LR04 and Lactobacillus plantarum LP02 are all probiotics with significant immune-enhancing effects.
Bifidobacterium animalis subsp. lactis BS01
* Enhance immune system function: Stimulate the activity of macrophages and natural killer cells (NK cells) in the immune system, enhancing the ability to fight pathogens.
Increases the production of antibodies (such as immunoglobulin A, IgA) to help fight infection.
* Reduces respiratory tract infections: Studies show that supplementing with BS01 can reduce the incidence of upper respiratory tract infections, especially in children and the elderly.
* Anti-inflammatory effect: Reduces intestinal and systemic inflammatory responses, helping to alleviate health problems related to chronic inflammation, such as allergies.
Lactobacillus rhamnosus LR04
*Regulate immune response: Promote the production of regulatory T cells (Treg) in the immune system, help maintain immune balance, and reduce allergic and autoimmune reactions.
*Enhance the intestinal immune barrier: Increase the number and activity of immune cells in the intestine, improve intestinal barrier function, and reduce the risk of intestinal infection.
*Reduces allergic reactions: Studies show that LR04 can reduce the incidence and severity of allergic diseases such as eczema and allergic rhinitis.
Lactobacillus plantarum LP02
Enhance systemic immune response: Stimulates different components of the immune system, including macrophages, T cells, and B cells, enhancing the overall immune response.
Increase the production of antibodies in the body and improve resistance to pathogens.
Antiviral properties: Studies have shown that LP02 can enhance host resistance to viral infections, particularly influenza viruses and enteroviruses.
Antibacterial effect: It has natural antibacterial properties and can inhibit the growth of harmful bacteria such as salmonella and E. coli, helping to prevent and reduce intestinal infections.
research support
Bifidobacterium animalis subsp. lactis BS01:
Clinical studies have shown that BS01 can significantly increase the activity of immune cells, reduce the incidence of respiratory infections, and help reduce the levels of inflammatory markers.
Lactobacillus rhamnosus LR04:
This probiotic has been shown to modulate the immune system, reduce allergic reactions, and demonstrate significant results in intestinal health and immune regulation.
Lactobacillus plantarum LP02:
Clinical trials have shown that LP02 can enhance systemic immune responses, particularly antiviral and antibacterial, and significantly increase antibody levels.
Practical application
Oral supplements: These probiotics are often available in the form of oral supplements that can be taken regularly to boost immunity.
In conclusion, Bifidobacterium animalis subsp. lactis BS01, Lactobacillus rhamnosus LR04, and Lactobacillus plantarum LP02 all demonstrated significant potential in enhancing immunity. They support and enhance the function of the immune system through a variety of mechanisms (such as enhancing immune cell activity, increasing antibody production, regulating immune responses, etc.) and help prevent and reduce infections and allergic reactions. It is recommended that you seek the advice of a medical professional before using these probiotic supplements, especially if you have a specific health condition or are taking other medications.
參考文獻 Reference:
[1] https://journals.lww.com/jcge/abstract/2018/11001/micronized_cells_of_the_probiotic_strain.11.aspx
Micronized Cells of the Probiotic Strain Bifidobacterium lactis BS01 Activate Monocyte Polarization
A New Approach
[2] https://www.frontiersin.org/articles/10.3389/fimmu.2021.578386/full
“Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body
“
[3] Microorganisms | Free Full-Text | Topical Administration of Lactiplantibacillus plantarum (SkinDuoTM) Serum Improves Anti-Acne Properties (mdpi.com)
注意: 本產品不能取代均衡飲食和健康的生活習慣。
Cautions: This product is a supplement, not a substitute for a balanced diet and healthy lifestyle habits
保存方式:
使用後，請保持瓶蓋緊閉，置放於攝氏25度以下 & 陰涼乾燥處，且兒童不易取得之處。
Keep the bottle tightly closed. Store in a cool, dry place (below 25℃) and avoid direct sunlight. Keep out of reach of children.
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